Search results for " oocyte quality"
showing 2 items of 2 documents
Lower apoptosis rate in human cumulus cells after administration of recombinant luteinizing hormone to women undergoing ovarian stimulation for in vi…
2007
Objective: To investigate the effects of recombinant (r-) LH supplementation in “low responder” patients undergoing ovarian stimulation with r-FSH for an IVF program. The apoptosis rate in cumulus cells was used as an indicator of oocyte quality. Design: Comparison of the rate of DNA fragmentation and caspase-3 activity in cumulus cells in women stimulated with r-LH and r-FSH, versus patients treated with r-FSH alone (control). Setting: In vitro fertilization (IVF) laboratory. Patient(s): Forty patients undergoing assisted fertilization programs treated with a GnRH agonist, or r-FSH treatment begun on day 3 of the cycle (control). In the r-LH group, from day 8 of gonadotropin stimulation, 1…
Inositol supplementation and IVF outcome: preliminary data
2012
Myo-Inositol (MI) is involved in several aspects of human reproduction. Elevated concentrations of myo-inositol in human follicular fluids, in fact, seem to play a positive role in follicular maturity, since to represent a possible marker of good oocyte quality. Nevertheless its positive role in PCOS patients is a consequence of a defect in the insulin signaling (inositol- containing phosphoglycan mediators) pathway that seems to be implicated in the pathogenesis of insulin resistance. The aim of this study was to analyze the effect of myo-inositol supplementation to “standard” therapy in PCOS women and in “poor responders”, submitted to In Vitro Fecundation (IVF) cycles. In particular, we …